Drag to reposition your photo
by on June 12, 2024
Adeno-associated virus (AAV) is a small non-enveloped virus, belonging to the family Parvoviridae. It was first discovered in 1965 from contaminants of adenovirus isolates. It has an icosahedral structure on the outside and a diameter of about 26 nm. Its capsid protein is composed of It is composed of three proteins: VP1, VP2 and VP3. The genome of AAV is a single-stranded linear DNA, approximately 4700 bp, including two upstream and downstream open reading frames (ORFs): Rep and Cap. They are l...
11 views 0 likes
by on June 12, 2024
Procalcitonin (PCT) is the propeptide of calcitonin. The production of procalcitonin during infection and sepsis does not depend on calcitonin levels, but is closely related to the release of endotoxin and inflammatory mediators in bacterial infection. Traditional biological markers, clinical symptoms, and signs lack sufficient sensitivity and specificity to guide treatment decisions for infectious diseases. As a recently applied biomarker, procalcitonin is increasingly supported by increasing e...
13 views 0 likes
by on May 13, 2024
GLP-2 (glucagon-likepeptide-2) was discovered and named by the Lilly Laboratory in the United States when cloning the proglucagon gene (PG). In 1996, Drucker et al. discovered that the active ingredient in proglucagon-derived peptide (PGDP) that promotes intestinal mucosal growth is GLP-2. Its effect is stronger than other growth factors that have been discovered, and its growth-promoting effect is organ-specific (limited to the stomach and intestine), GLP-2 began to be valued and studied. Subse...
24 views 0 likes
by on May 13, 2024
Genetically engineered drugs are introduced into host cells such as Escherichia coli, yeast or mammalian cells through recombinant technology to construct engineering strains or cell strains, and then undergo specific expression, assembly, folding and post-translational modification processes to produce drugs with corresponding Bioactive macromolecules. Endogenous proteins derived from host cells are called host cell proteins (HCPs). Their composition is complex. Depending on the selected host c...
26 views 0 likes
by on April 8, 2024
Staphylococcus aureus (S. aureus) is an important class of food-borne pathogens that cause food contamination and food poisoning, and is also a symbiont of human skin and mucous membranes. Studies have found that about 20%~30 % of healthy individuals carry Staphylococcus aureus. Animal foods are susceptible to Staphylococcus aureus infection, such as milk, butter, cured ham, etc. Food poisoning incidents caused by Staphylococcus aureus have been frequently reported, and more than 95% of them are...
29 views 0 likes
by on April 8, 2024
The incidence and prevalence of diabetes are increasing year by year globally, and patients with diabetes are at increased risk of cardiovascular disease and heart failure. Diabetic cardiomyopathy (DCM) refers to the presence of abnormal myocardial structure and performance in the absence of other heart-related risk factors (such as coronary artery-related disease, hypertension, and severe valvular disease). DCM can lead to cardiac systolic or diastolic dysfunction, further causing heart failure...
32 views 0 likes
by on March 13, 2024
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with an insidious onset. Clinically, it is characterized by comprehensive dementia manifestations such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavioral changes. Alzheimer’s disease is progressive and irreversible and can only be delayed with medication. Once it develops into moderate or severe disease, it will cause significant harm to the l...
42 views 0 likes
by on March 13, 2024
Herpes simplex virus (HSV) belongs to the herpesvirus alpha subfamily and has a unique 4-layer structure. The core of HSV is a linear double-stranded DNA of about 152 000 bp, surrounded by an icosahedral capsid. The outer capsid is a membrane, which contains more than 20 important proteins that can regulate the virus replication cycle. It is a characteristic structure of herpes viruses, can connect the capsid and envelope to form a complete virus particle. The outermost layer of HSV is the lipid...
38 views 0 likes
by on February 19, 2024
The tumor microenvironment is composed of tumor cells and non-tumor cells (including fibroblasts, vascular and lymphatic endothelial cells, various immune cells) and extracellular components (such as extracellular matrix, cytokines, inflammatory factors, chemokines, etc.) in tumor tissues. Factors, etc.) interact to form a dynamic and complex network structure. Among them, chemokine receptors can participate in a variety of physiological and pathological processes after binding to their ligands,...
40 views 0 likes
by on February 19, 2024
As a tumor suppressor, p53 is one of the most commonly mutated genes in human cancers. Due to its important role in tumor suppression, p53 has attracted great interest from researchers in drug development. As a transcription factor, p53 is directly or indirectly involved in regulating many genes, including cell cycle arrest, apoptosis, senescence, and DNA repair. In recent years, p53 has become one of the most important and attractive drug targets in cancer treatment. This article will review re...
36 views 0 likes
by on January 19, 2024
Creative Diagnostics offers proprietary genetic immunization based polyclonal and monoclonal antibody generation services. This unique antibody development approach involves direct immunization of host animals with plasmid DNA encoding the target protein of interest. The immunized hosts then produce the encoded protein and raise antibodies. Genetic immunization involves introducing the gene in the form of a cDNA directly into an animal which translates this cDNA into protein thus stimulating an ...
63 views 0 likes
by on January 19, 2024
Creative Diagnostics staff scientists have extensive antibody purification experience. We have developed robust proprietary purification procedures for antibodies from serum, ascites fluid, yolks and culture supernatants for use in early discovery research, preclinical trials and in vitro medical devices. All purified antibodies can be analyzed by electrophoresis, ELISA, western blot and HPLC to determine purity and integrity. Corresponding test data will be provided to the customer. Availabl...
60 views 0 likes