Acetylation is one of the major protein modifications in cells, where the acetyl group from acetyl coenzyme A (acetyl-CoA) is transferred to a polypeptide chain. Protein acetylation can occur at N-terminal as a co-translational covalent modification by N-terminal acetyltransferases (NATs), or on lysine as a reversible post-translational modification (PTM). Like phosphorylation, acetylation also affects protein function by altering the properties of proteins such as hydrophobicity, solubility, protein conformation and affinity with other macromolecules.
Thousands of acetylation have been identified in human proteome, among which chromatin proteins and metabolic enzymes are highly represented such as histones, P53, and STAT3. Consequently, dysregulation of acetylation can lead to metabolic disorders, cancers, neurodegeneration, and cardiovascular diseases.
CD BioSciences offers a complete portfolio of solutions to study protein acetylation including acetylation profiling, acetyltransferase/deacetylase identification, substrate identification, and inhibitor/activator screening.
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Michelle MoserFounder