Creative Diagnostics offers proprietary genetic immunization based polyclonal and monoclonal antibody generation services. This unique antibody development approach involves direct immunization of host animals with plasmid DNA encoding the target protein of interest. The immunized hosts then produce the encoded protein and raise antibodies. Genetic immunization involves introducing the gene in the form of a cDNA directly into an animal which translates this cDNA into protein thus stimulating an ...

Creative Diagnostics staff scientists have extensive antibody purification experience. We have developed robust proprietary purification procedures for antibodies from serum, ascites fluid, yolks and culture supernatants for use in early discovery research, preclinical trials and in vitro medical devices. All purified antibodies can be analyzed by electrophoresis, ELISA, western blot and HPLC to determine purity and integrity. Corresponding test data will be provided to the customer. Availabl...

Caenorhabditis elegans (C. elegans) is a free living, transparent nematode with a length of about 1mm. It is common around the world and lives in temperate soil environments. C. elegans is an unsegmented pseudocoelomate that lacks a circulatory system and a respiratory system. It is non-hazardous, non-pathogenic, non-infectious and non-parasitic Caenorhabditis elegans is small (with a length of about 1mm) and transparent for ease of manipulation and observation. Thus it is safely used in the lab...

Saccharomyces is a genus of fungi that contains dozens of yeast species, such as Saccharomyces arboricolus, Saccharomyces bayanus, Saccharomyces ellipsoideus, Saccharomyces florentinus, Saccharomyces kluyveri, etc. Many species of Saccharomyces play important roles in food industry (e.g. Saccharomyces cerevisiae is used in making bread, beer and wine). Saccharomyces colonies are flat, moist, smooth, glistening or dull, and cream in color. They grow rapidly and mature in three days. Members of Sa...

The ability to sense the presence of microorganisms that could cause potentially dangerous infections is a widespread property of cells, tissues and body fluids of all multicellular organisms. This process is called innate immune recognition. This recognition process is the first crucial step triggering the complex sequence of events by which the body protects itself against infection. However, it is only since the 1980s that most of the molecules (receptors) responsible for this recognition pro...

PDK-1 overview Protein 3-phosphoinositide-dependent protein kinase-1 (PDK-1) As a member of AGC kinases family, PDK-1, a protein of 556 amino acids, is composed of serine and threonine kinases. The catalytic domain of these serine and threonine kinases show a sequential similarity with cAMP-dependent protein kinase 1 (PKA), cGMP-dependent protein kinase (PKG) and protein kinase C (PKC). There are two phosphorylation sites that many AGC kinases and they are to regulate the activity of AGC k...