Introduction
Peptides play an important role in regulating the functional activities of various systems, organs, tissues and cells in the body and life activities, and are often used in disease research, cosmetics, drug research and development and other fields. Peptides can be divided into cyclic and linear peptides according to whether they are cyclic or not. The synthesis technology of linear peptides is very mature. The synthesis of linear peptides consisting of hundreds of Amino Acid has b...
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When parts or the whole of certain tissues or organs fail, there are several options for treatment, including repair, replacement with a synthetic or natural substitute, or regeneration. The fabrication of a cell scaffold with hydrogel derived from natural polymer materials is an attractive method to be applied for tissue engineering, but some undesirable mechanical properties and immunogenic risks of natural hydrogel are a dilemma for this kind of application. However, PEG is a promising raw ma...
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Over the years, the absolute quantification (AQUA), based on isotope-labeled peptides has become a resultful means of quantifying proteins. AQUA can quantitatively study various complicated biological samples and provide valuable new tools for proteomics.
Properties of AQUA Peptides
The target peptides of the protein to be quantified should be able to ionize effectively and be easily detected by mass spectrometry (MS).
The target peptides should avoid containing methionine and cysteine and ...
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What are exosomes?
Exosome is a type of extracellular vesicle (EV) with a diameter of about 30-150 nm. They are secreted by all cell types and can be found in most body fluids, including blood, saliva, and urine. Exosomes are "nanospheres" with bilayer membranes, which contain a wide array of substances from parent cells, such as microRNAs, mRNA expression, lncRNA, DNA, lipids, peptides, and proteins (including oncoprotein, Tumor suppressor genes, transcription regulators and splicing factors)....
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In the past few years, there has been a great interest in a class of promising drugs, which do not work by inhibiting the molecular target as most traditional drugs do, but use the cell recovery system to destroy the target. However, it is difficult to find and design such unusual compound drugs, which are collectively called the molecular glue degraders.
Now, a new molecular glue-degrading agent called CR8 was discovered by scientists at the Broad Institute in the United States and the Fried...
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Introduction
Amino acids, vitamins, and minerals are essential substances for humans. Therefore, many foods add these substances to complete the body’s nutritional supplement. Amino acids, vitamins, and minerals are essential substances for human beings. Therefore, many foods add these substances to complete the body’s nutritional supplement. However, many amino acids, vitamins, and minerals are susceptible to oxidative denaturation or photolysis caused by external environmental influences su...
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What are exosomes?
Exosome is a type of extracellular vesicle (EV) with a diameter of about 30-150 nm. They are secreted by all cell types and can be found in most body fluids, including blood, saliva, and urine. Exosomes are "nanospheres" with bilayer membranes, which contain a wide array of substances from parent cells, such as microRNAs, mRNA expression, lncRNA, DNA, lipids, peptides, and proteins (including oncoprotein, Tumor suppressor genes, transcription regulators and splicing factors)....
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Isotopes refer to different atoms of the same element, whose atoms have the same number of protons but different numbers of neutrons. The discovery of isotopes makes people have a deeper understanding of atomic structure. This not only gives a new meaning to the concept of elements, but also significantly revolves the benchmark of relative atomic mass, which confirms that the proton number, also called the nuclear charge number, is the key to the chemical properties of elements, not the atomic m...
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As an amphiphilic polymer, PEG can be soluble in water and most organic solvents, and has the characteristics of good biocompatibility, non-toxicity, and low immunogenicity. It can be excreted through the kidneys, so there will be no accumulation phenomenon in the body. For a long time, PEG is a commonly used as pharmaceutical excipient, which has been widely applied in various medicaments such as soft ointment, suppository, drop pill, hard capsule, eye drop, injection and tablet.
Role o...
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Staudinger ligation is to capture the intermediate of azaylide with electrophilic groupsgenerally located on triaryl phosphines, and act in aqueous medium to obtain the intramolecular amido phosphine oxide after rearrangement.
Introduction
Staudinger ligation is a metal-free catalytic click reaction between organic azide and phosphine and it belongs to a bio-orthogonal reaction. It has the following three elements: the reaction must occur in aqueous solution, the catalyst or reactant invol...
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