Half-life Extension Service by Genetic Manipulation

Studies conducted recently indicate that a molecule can become highly protease resistant in vivo by substituting just one amino acid. Long-acting interferon beta preparation has made use of the point mutation of interferon. A phase 1 trial was initiated for an enhanced somatropin formulation based on genetic alteration. Numerous successes attest to the fact that point mutation has emerged as a novel technique for improving the pharmacokinetics of proteins and is frequently employed in therapeutic protein research. The drug development market has high expectations for half-life extension by genetic manipulation as a unique, practical, and one-stop solution for half-life extension.