Stable cell lines are useful for applications in toxicological and pharmacological research, drug screening, and the production of therapeutic and diagnostic antibodies. With a wealth of expertise in developing stable cell lines, Creative Biolabs has already established the stable Fut8 knockout CHO cell line, Fucoanalog™, and Glymax™ cell lines for the generation of ADCC? antibodies. In particular, ADCC/CDC assay development, ADCC/CDC functional investigations, and other related fields can benef...

In the fields of tissue engineering, stem cell research, regenerative medicine, and embryology, patients will be treated with cell surface modification technology, an emerging field of study. We have a great deal of experience because we have spent years specializing in cell membrane engineering services. Our solid foundations and professional experience enable us to confidently offer dependable cell surface-based polymer conjugation services. In regenerative medicine, cell surface modification...

Pectic acid, also called polygalacturonic acid, is a clear, water-insoluble gelatinous acid that can be found in various vegetables and overripe fruit. It is created when pectinase and pectin interact, a process that results from the breakdown of pectin in plants (the latter being widespread in the wine-making sector.) The pectic material found in fruits during their early growth is a water-insoluble protopectin, which is transformed into pectin by the fruit ripening enzyme protopectinase. Becau...

The development of cancer 3D models is to simulate the microenvironmental features of in vivo tumor growth along with the phenotypic and cellular heterogeneity of tumors. As in vivo tumors grow, 3D models more accurately mimic the complexity and variety of clinical malignancies than do 2D cell cultures. Numerous in vivo tumor features, including cell-cell communication, hypoxia, drug penetration, response, and resistance, as well as extracellular matrix synthesis and deposition, have been found ...

The process of using analytical methods to solve a molecule's or biomolecule's three-dimensional atomic coordinates is known as antibody structure determination. Antibody structure is determined using a range of techniques, including density maps from cryo-electron microscopy, X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and more. With years of expertise in antibody engineering, Creative Biolabs provides clients with top-notch services for determining antibody structures...

γ-polyglutamic acid is a naturally occurring biopolymer made of single glutamic acid, which was initially identified as the main constituent of the Bacillus anthracis capsule. γ-polyglutamic acid encompasses γ-(D)-polyglutamic acid, γ-(L)-polyglutamic acid, and γ-(D,L)-polyglutamic acid as a broad term. Researchers are interested in γ-polyglutamic acid because of its water solubility, edibility, and environmental friendliness as a polypeptide. γ-polyglutamic acid has shown promise in recent deca...

Western blotting (WB), when used in conjunction with polyacrylamide gel electrophoresis, is a crucial analytical method and technique in the biological sciences. It is still a highly effective diagnostic method used in medical labs. However, its technique involves several steps that are often low throughput, resource- and time-intensive. These days, a microfluidic western blotting (μWB) technique has been developed utilizing advancements in microfluidics to greatly optimize resources and mini...

Expressed as a fusion protein with the appropriate tag, a protein of interest can be powerfully used to define its features. But each probe is customized for a particular protein and use, necessitating a significant financial outlay. The majority of proteins can be bound to target molecules with fluorescent tags easily and often using SNAP-tag. A human O6-alkylguanine-DNA alkyltransferase (AGT) mutant known as SNAP-tag allows for the irreversible labeling of particular areas with O6-benzylgua...

The two subunits that make up each ribosome structure are small and huge, and they come together to convert messenger RNA sequences into proteins before splitting apart. They will reassemble, though maybe not with the same partners, when a new protein needs to be made. They are really jumbled to some degree. Attempts to create ribosomes that can include additional substances or non-native amino acids are hampered by this mixing. The ability of the cell to create normal proteins may be diminished...

There are many potential uses for scFv-CH-CL-scFv in cancer immunotherapy, particularly in the synthesis of chimeric antigen receptors (CARs). A transmembrane structure, an endogenous signal transduction structure, and an exogenous antigen recognition structure (often a scFv or scFv-CH-CL-scFv) make up the artificially manufactured protein known as CAR. T cells can be transduced with CAR, which gives them the ability to identify and eliminate tumor cells that express particular antigens directly...

With our RT-LAMP assays, probable SARS-CoV-2-affected samples can be found in as little as one to two hours—all without the need for costly equipment or highly skilled personnel. In addition, we have created a one-step RT-LAMP platform to monitor sensitive populations for SARS-CoV-2, which can offer valuable information for prompt decisions about SARS-CoV-2 management measures. We can measure and analyze samples with the lowest concentration (10−5 PFU) using this platform. Furthermore, RT-LAMP t...