Liver Cirrhosis

Liver cirrhosis (LC) is a widespread process defined by fibrosis and the transformation of normal liver architecture into structurally aberrant nodules surrounded by annular fibrosis. It is the final stage of many kinds of chronic hepatitis of various etiologies. Hepatocellular carcinoma (HCC) may develop more quickly as a result of liver cell loss and portal hypertension caused by this long-term, progressive clinical disease. Alcohol, hepatitis B, hepatitis C, and nonalcoholic steatohepatitis (NASH) are the most common causes of cirrhosis.

Cirrhosis Diagnostic Development

Two phases can be distinguished in clinical LC: compensated and decompensated. While compensated LC may be challenging to distinguish from chronic hepatitis, decompensated LC is easily recognized due to its array of clinical and biochemical symptoms, which include ascites, sepsis, variceal hemorrhage, encephalopathy, and non-obstructive jaundice. Therefore, it is essential to accurately assess the fibrosis stage or the emergence of overt cirrhosis in order to make an accurate diagnosis, initiate appropriate treatment, or enable early detection of the common and deadly complications of LC, such as esophageal varices and HCC.