Topic: fc-fusion protein development

Because of FcRn-mediated recycling, IgG molecules belonging to the IgG1, IgG2, and IgG4 subclasses have remarkably extended half-lives. Therapeutic antibodies have been reported to have half-lives as long as four weeks. The CH2 and CH3 domains combine to produce the binding site for FcRn, which is located in the Fc region. Therefore, fusing to an Fcγ region confers on a therapeutic protein the immunoglobulin half-life extension features (larger size, FcRn recycling). Most fusion proteins have be...