Topic: genetic manipulation

Studies conducted recently indicate that a molecule can become highly protease resistant in vivo by substituting just one amino acid. Long-acting interferon beta preparation has made use of the point mutation of interferon. A phase 1 trial was initiated for an enhanced somatropin formulation based on genetic alteration. Numerous successes attest to the fact that point mutation has emerged as a novel technique for improving the pharmacokinetics of proteins and is frequently employed in therapeuti...