With years of experience in the pharmaceutical and life science sectors, CD Bioparticles announces the availability of its new line of Basic Agarose Particles for efficient biomolecule separation. These versatile, unmodified agarose microspheres offer researchers a powerful tool for various applications, including protein purification, negative controls in experiments, and the foundation for further functionalization.
Basic agarose particles are non-preactivated agarose microspheres. The unmodified and unactivated particles are useful for removing proteins and other samples containing components that bind non-specifically to agarose, thereby reducing background signal and non-specific binding in IP and Co-IP experiments. They can also be used as negative controls to distinguish between specific and non-specific interactions.
Agarose derivatives are ideal supports for affinity chromatography, ion exchange chromatography and hydrophobic interaction chromatography. Cross-linked agarose particles are high-density agarose particles with more cross-linked polysaccharide chains. As a result, they have significantly improved chemical stability and physical properties and can withstand higher pressures. These particles provide researchers with a powerful toolkit to enhance their experiments and accelerate scientific discovery.
Committed to advancing bio-research with innovative solutions, CD Bioparticles offers a variety of Basic Agarose Particles for efficient separations, including 1) Control Agarose Particles, 4% cross-linked, unmodified for use as negative controls or to remove proteins and other non-specifically bound sample components in IP and Co-IP assays, and 2) High Flow Agarose Particles, with a maximum linear velocity of up to 1000 cm/h at 15 cm bed height and a maximum working pressure of up to 300 kPa, suitable for high pressure separations such as FPLC and HPLC.
Non-crosslinked and highly crosslinked basic agarose particles with different particle sizes and agarose contents are also available upon request. In addition, CD Bioparticles offers autoclavable basic agarose particles that can withstand temperatures up to 120°C. With a broad fractionation range from 10 kDa to 4000 kDa, these particles exhibit low non-specific adsorption due to removing charged impurities from refined agarose. Their particle size spans 45 µm to 200 µm, ensuring high recovery rates and multiple reuses.
These versatile particles, meticulously crafted by CD Bioparticles’ experienced team, empower researchers across diverse fields with precision and reliability. They can serve as essential tools for pre-clearing protein samples, reducing background signal and nonspecific binding in immunoprecipitation (IP) and co-immunoprecipitation (Co-IP) assays. Additionally, these particles act as negative controls, distinguishing specific from nonspecific interactions. When further functionalized, agarose particles become supports for affinity chromatography, ion exchange chromatography and hydrophobic interaction chromatography. Researchers can tailor the functionality of agarose beads to suit specific applications.
CD Bioparticles offers versatile Basic Agarose Particles for efficient isolation and purification of biological macromolecules. For more information and to explore the full range of new products, please visit CD Bioparticles at https://www.cd-bioparticles.com/products/basic-agarose-particles-1064.html.
About CD Bioparticles
CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.
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CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, has recently expanded its low PDI polymer portfolio and announces its new offering of Polyolefin Family polymers with a wide range of properties that make them well-suited for a variety of drug delivery applications.
Low dispersion index polymers are polymeric compounds with low molecular weight dispersion. Typically, the structures of such polymers are designed to reduce their dispersion in solution, thereby improving their stability and controllability. They’re widely used as drug carriers mainly because of their ability to efficiently carry and release drug molecules, thereby improving drug bioavailability and therapeutic efficacy. The design of such drug carriers also helps to overcome some of the limitations of conventional drugs such as biostability, water solubility and drug distribution in the body.
The Polyolefin family is a class of polymers derived from simple hydrocarbons with a wide range of promising drug delivery applications. These materials, which include polyethylene and polypropylene, have a number of unique properties suitable for various pharmaceutical applications. For example, Polyolefins’ inertness, biocompatibility, and ability to be tailored to specific drug release profiles make them particularly attractive for the design of drug delivery systems.
In addition, Polyolefin-based drug delivery systems offer excellent stability, ensuring that drug formulations remain intact over time. The biodegradability and minimal toxicity of Polyolefins also make them attractive for the development of sustained-release formulations. Moreover, the tunable properties of Polyolefins allow modulation of drug release kinetics, resulting in precise control of the therapeutic dose.
This family of polymers has proven advantageous in improving the efficacy and safety of drug release and overcoming the challenges associated with conventional formulations. As research continues, the Polyolefin family will continue to attract the attention of scientists and pharmaceutical experts, demonstrating its potential to revolutionize drug delivery strategies and improve patient outcomes.
CD Bioparticles recognizes the potential of the Polyolefin family for pharmaceutical applications and has developed innovative drug delivery systems using Polyolefins based on their inherent properties. The company is committed to working with partners on a number of research and development projects aimed at delivering a variety of drugs using Polyolefins and bringing these novel drug delivery systems to market. Furthermore, CD Bioparticles strives to make further groundbreaking contributions to the field of drug delivery and will continue to honor its commitment to innovation.
With a focus on improving drug efficacy and patient outcomes, CD Bioparticles has harnessed the unique properties of Polyolefin to enhance drug delivery applications. To learn more about new polymers and other products from CD Bioparticles, please visit https://www.cd-bioparticles.net/polyolefin-family.
About CD Bioparticles
CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.
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With years of experience in the pharmaceutical and life science sectors, CD Bioparticles proudly announces the launch of its latest product line of Agarose Particles for isolation and purification of proteins and antibodies. These versatile microspheres, available in diameters ranging from 25 nm to 500 µm, empower researchers with a powerful tool for a wide range of applications.
Agarose particles are porous gel microspheres that, depending on their size, can filter or separate mixtures of molecules. These particles are easily activated to bind reversibly or irreversibly to biomolecules. They can be used for batch or column purification of proteins and antibodies and are well suited for biopharmaceutical applications. In addition, their large internal porosity allows the purification of larger biomolecules such as monoclonal antibodies. Meanwhile, their particle size distribution is mainly between 20 and 300 μm. Small particle sizes are suitable for very high resolution polishing steps, while large particle sizes are suitable for capture steps. Furthermore, the volume required also influences the choice of particle size, as large volumes typically require larger particle sizes.
Agarose particles are available in different percentages, e.g., 2%, 4% and 6%, allowing better separation of molecules according to their size. Particles with a higher percentage of agarose are suitable for separating small globular proteins due to their smaller pore size. Similarly, particles with a lower percentage of agarose are more suitable for separating larger globular proteins. In addition, preactivated agarose particles can be used to bind biomolecules. Particles with proteins and antibodies on the surface are used as affinity chromatography resins, ion exchange chromatography resins, size-exclusion chromatography resins, and hydrophobic interaction chromatography resins. Enzyme-immobilized agarose particles can be used for antibody fragmentation.
CD Bioparticles offers a wide range of agarose particles, including Basic Agarose Particles, Functional Agarose Particles and Conjugated Agarose Particles. These precision-engineered agarose particles elevate research and separation processes in various applications, such as isolation and purification of proteins with affinity tags and antibodies, preparation of antibody fragments, and conjugation of proteins, antibodies and peptides. These particles can also be used in pull-down assays, chromatin immunoprecipitation assays and immunoprecipitation assays.
For example, DiagAg™ Carboxyl Agarose Particles, 25 μm (DAG-BE23-01) have good rigidity and monodispersity. Their surface is modified with abundant carboxyl groups (-COOH), which allows them to bind to biological ligands containing primary amine groups such as proteins, antibodies, oligonucleotides and drug molecules by covalent coupling methods. These new products are an important support tool for molecular biology and medical research.
CD Bioparticles is committed to providing valuable tools to researchers in the biopharmaceutical and life science fields. For more information and to explore the full range of Agarose Particles, please visit CD Bioparticles at https://www.cd-bioparticles.com/products/agarose-particles-1063.html.
About CD Bioparticles
CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.
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CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, announced the launch of its expanded line of low-PDI polymers, Polyacrylamides. The new product line offers different functional groups (e.g., acid, amine, and methoxy) and a variety of molecular weights (1.5 KDa-6,000 KDa), making them ideal for a wide range of applications, particularly for drug delivery.
Low dispersion index polymers are a class of low molecular weight polymeric compounds. Typically, the structures of such polymers are designed to reduce their dispersion in solution, thereby improving their stability and controllability. Such polymers have important applications in the field of drug delivery, mainly due to their ability to efficiently carry and release drug molecules, thus improving drug bioavailability and therapeutic efficacy.
Low PDI polymers offer several key benefits in drug delivery. These polymers have precise and controllable properties, making it easier to tailor their structure during synthesis for specific application requirements. Additionally, they exhibit higher reaction efficiencies due to their narrower molecular weight distribution, resulting in uniform polymer structures. This uniformity contributes to stable drug carriers and controlled drug release. Moreover, low PDI polymers enable targeted drug delivery by allowing better control over carrier shape and surface properties, thereby concentrating drugs at the diseased site while minimizing impact on normal tissues. In summary, these polymers play a crucial role in advancing drug delivery systems by improving stability, precision, and therapeutic outcomes.
Polyacrylamides are water-soluble synthetic linear polymers made from acrylamide or the combination of acrylamide and acrylic acid. With a commitment to excellence and sustainability, CD Bioparticles has expanded its portfolio of low PDI polymers to offer the research community a wide range of Polyacrylamides with functional groups (e.g., acid, amine, cyanide, and methoxy) and a variety of molecular weights (1.5 KDa-6,000 KDa). These new products can be used for various applications, including drug delivery, wound healing, and tissue engineering.
CD Bioparticles’ quality polyacrylamide products can help scientists address critical challenges in drug delivery, including the low water solubility of drugs, their susceptibility to environmental factors (e.g., light, oxygen and humidity), the need for targeted delivery, controlled release, and combination therapy. By encapsulating drugs within these polymers, CD Bioparticles enhances drug bioavailability, stability, and precision while facilitating joint administration of multiple drugs. CD Bioparticles’ innovative solutions contribute to advancing drug delivery research and improving patient outcomes.
CD Bioparticles is committed to advancing drug delivery research and leveraging the power of polyacrylamide to create innovative solutions that help its customers achieve their research goals. To learn more about new polyacrylamides and to explore other low-PDI polymers from CD Bioparticles, please visit https://www.cd-bioparticles.net/polyacrylamide.
About CD Bioparticles
CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.
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With years of experience in the pharmaceutical and life science sectors, CD Bioparticles has announced the expanded portfolio of its new Particles for Solid Phase Organic Synthesis, including functional resins, preloaded resins and resins for special synthesis, providing a more efficient and time-saving method for the synthesis of small molecules, peptides and oligonucleotides.
Solid Phase Organic Synthesis (SPOS) is a method in which molecules are covalently attached to a solid support and chemically synthesized stepwise using selective protecting groups. This method offers many significant advantages over conventional solution phase synthesis methods, including purification of the product by simple filtration of the polymer matrix, automation, ease of handling, low moisture susceptibility, minimal side reactions, no need for polymerization due to targeted separation of polymer particles, and recyclability of the polymer matrix for reuse. As a result, the time required for separation is very short and predictable.
The traditional support materials are polystyrene (PS)-based resins and polyethylene glycol (PEG)-grafted PS resins. The presence of PEG makes the resins compatible with polar solvents, especially water. SPOS is widely used in organic synthesis, particularly in the field of drug discovery, where efficient synthesis is highly desirable for high-throughput screening and optimization. In addition, with the advent of solid-phase technology, solid-phase peptide synthesis (SPPS) has become a more practical part of scientific research today.
CD Bioparticles now offers a range of functional resins and preloaded resins to meet the needs of small molecule, peptide, and oligonucleotide synthesis. Available in a variety of diameters (from 40 µm to 560 µm) and linker types, these SPOS particles offer excellent chemical and mechanical stability, efficient isolation of intermediates, and improved reaction conversions, making them well suited for high-efficiency synthesis.
The particles can be used in a wide range of applications, including general peptide synthesis, long peptide synthesis, small molecule synthesis involving acylation and alkylation, Michael addition, reductive amination, oligonucleotide synthesis, and multi-antigen peptide synthesis for polymerization of immunoconjugates.
For example, the DiagSupport™ H-Ala-2-Chlorotrityl Polystyrene/DVB Resin (Cat. No. SPS-AP23-001) have a copolymer matrix of copolymerized (styrene-1% DVB) and a particle size of 100-200 mesh. Since the attached amino acids are N-deprotected, these resins can be used without pretreatment. The resins are very acid sensitive and suitable for the synthesis of protected peptide fragments by Fmoc strategies. The finished peptides can be cleaved under very mild conditions to obtain protected peptides for further processing or under standard acidic conditions to obtain fully deprotected peptides.
These new offerings hold great promise for researchers and scientists in the field of organic synthesis. For more information about CD Bioparticles’ new particles for SPOS, please visit https://www.cd-bioparticles.com/products/particles-for-solid-phase-organic-synthesis-1074.html.
About CD Bioparticles
CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.
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CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, is thrilled to announce the launch of its latest innovation in the field of polymers, a new range of Low PDI Polymers. These cutting-edge polymers are specifically designed to deliver enhanced performance in various applications, such as drug delivery.
Polymers with low polydispersity index (PDI) have a narrow molecular weight distribution, which allows for better control of their properties and ensures consistent performance from batch to batch. This unique characteristic makes these polymers popular for a variety of applications. For instance, resins or polymer systems used for creating durable thin coatings benefit from a lower PDI. This is because they provide high-performance coatings that are thin and have excellent adhesion, abrasion, scratch, and chemical resistance.
CD Bioparticles now offers a wide range of Low PDI Polymers, including Polyacrylamide, polystyrene, Polysiloxane, Fused Heterocycle Polymers, Hydrophilic Polymers, and Hydrophobic Homopolymers. These polymers have a narrow molecular weight distribution, making them ideal for various applications such as drug delivery.
For example, the Poly vinyl alcohol (Catalog: CDP23-251-L) is produced through the hydrolysis of poly vinyl acetate under alkaline conditions. Poly vinyl acetate is synthesized through a free radical polymerization reaction using ethyl acetate iodine as a chain transfer reagent. The polymerization reaction is conducted in bulk.
The company also provides biodegradable polymers, monomers, fluorescent polymers, and PEG conjugations to tackle various drug delivery challenges. Its advanced technology platforms provide solutions for complex chemical synthesis, formulation, purification, and the need for functional groups for further modification, conjugation, or cross-linking.
Additionally, CD Bioparticles offers solutions to achieve cell-specific or tissue-specific targeting of nanomedicines. These solutions overcome the difficulties of tracking and imaging the distribution of polymeric (nano) materials, improve drug loading efficiency and yields, address immunoreactivity or xenobiotic reactions, prevent rapid clearance of drug carriers, and control delivery profiles.
CD Bioparticles is dedicated to providing its customers with the highest quality products and services. The company’s team of professionals is readily available to address inquiries and offer advice on product selection and usage. In addition to its diverse product range, CD Bioparticles offers exceptional customer support, providing expert guidance and technical assistance to researchers worldwide.
CD Bioparticles provides comprehensive solutions for drug delivery scientists, specializing in customized delivery strategies, precise drug design, and modifications of drug-contained cargos. To learn more about CD Bioparticles' Low PDI Polymers and to explore their applications, please visit https://www.cd-bioparticles.net/low-pdi-polymers.
About CD Bioparticles
CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.
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With years of experience in the pharmaceutical and life science sectors, CD Bioparticles has announced the launch of its new line of Plain Polystyrene Particles in various diameters ranging from 25 nm to 750 µm. These versatile particles offer researchers a powerful tool for a wide range of applications, from protein adsorption and immunoassays to bioseparations and drug delivery.
Polystyrene particles are prepared by emulsion and emulsion-free polymerization processes. Coated or conjugated particles are prepared by passive adsorption or covalent coupling. Functionalized polystyrene nanoparticles and polystyrene particles can be used for a variety of applications such as drug delivery materials, bioimaging, markers and immunoassays.
Polystyrene particles provide a flexible platform for diagnostic and bioseparation applications. There are several methods for adsorbing biological ligands onto polystyrene particles. These methods include adsorption onto plain polystyrene particles, covalent attachment onto surface functionalized particles, and adsorption of ligands of interest onto particles precoated with binding proteins (e.g., streptavidin, protein A, or protein G).
CD Bioparticles now offers a range of Plain Polystyrene Particles from 25 nm to 750 µm in diameter for a variety of applications. For example, the DiagPoly™ Plain Polystyrene Particles, 0.025 μm (Cat. No. DMP-L001) can be used as standards or markers, in immunoassays (such as latex agglutination assays and solid phase enzyme immunoassays), or coated with proteins for use in research and diagnostic tests. In addition, the company’s experienced chemists control the synthesis process to provide a precise monodisperse particle size distribution.
Polystyrene particles are slightly negatively charged due to the surface charge from the initiator fragments used to initiate the polymerization reaction. By convention, these particles are considered plain or neutral particles because they are not specifically functionalized. These monodisperse polystyrene particles, also known as latex microspheres, can be used in a variety of applications such as immunodiagnostic assays, size standards for instrument calibration, and cell biology applications.
CD Bioparticles’ proprietary formulation and process technology produces microspheres with excellent size uniformity. These polystyrene microspheres provide a flexible platform for diagnostic and bioseparation applications. They can be coated with recognition molecules such as antigens, antibodies or peptides, and can also be loaded with hydrophobic dyes and other compounds.
These Plain Polystyrene Particles offer a winning combination of versatility and performance. Non-toxic, odorless and highly transparent, these microspheres offer a range of sizes, impressive stiffness and chemical resistance, and a remarkably uniform surface ideal for passive adsorption. From protein adsorption and diagnostic assays to electron microscopy, instrument calibration, and even coating materials for contrast agents and anti-cancer drugs, CD Bioparticles’ Plain Polystyrene Particles can help customers realize these applications.
These new offerings cater to diverse research needs, providing scientists with a reliable and versatile tool for a wide spectrum of applications. For more information on CD Bioparticles' Plain Polystyrene Particles, please visit https://www.cd-bioparticles.com/products/plain-polystyrene-particles-319.html.
About CD Bioparticles
CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.
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CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, has announced an expanded portfolio of Polydimethylsiloxane (PDMS) products, empowering researchers with versatile and biocompatible tools for groundbreaking discoveries.
Polydimethylsiloxane is an elastomeric polymer with interesting properties for biomedical applications, including non-physiological reactivity, excellent resistance to biodegradation, biocompatibility, chemical stability, gas permeability, good mechanical properties, excellent optical transparency, and easy replication molding. Based on these properties, PDMS has been used in a wide range of applications such as micropumps, catheter surfaces, dressings and bandages, microvalves, optical systems, in vitro disease studies, implants, microfluidics, and photonics.
In addition, PDMS is the most widely used material for the manufacture of microfluidic devices, which are an important technology for the development of systems for drug delivery, DNA sequencing, clinical diagnostics, point-of-care testing, and chemical synthesis. The materials used in these systems should be biocompatible, optically transparent, rapid to prototype and low cost to manufacture, characteristics of PDMS.
In the pharmaceutical field, PDMS derivatives have been widely used as coatings for controlled drug delivery systems. The main advantages of these materials are the ease of tuning the desired drug release pattern, improved film formation and storage stability. Recognizing its immense potential, CD Bioparticles has significantly broadened its PDMS offerings to cater to the evolving needs of researchers, including PDMS Grafted Triethoxysilane, Si-PSSNa, Butyl-PDMS-Triethoxysilane, and Cyclocarbonate-PDMS-Cyclocarbonate.
CD Bioparticles offers various Biopolymers & Synthetic Polymers for customers worldwide. CD Bioparticles is committed to easing the burden on its customers by reducing cumbersome chemical synthesis, formulation and purification, improving drug loading efficiency and yield of drug delivery materials, and helping customers track and image the distribution of polymer-based (nano)materials to avoid strong immunoreactivity or xenobiotic reactions to the materials.
CD Bioparticles can provide customers with a wide range of functional groups/targeting ligands/tags covering polymers for loading, modification, specific targeting, tracking and detection, as well as functional groups in different densities or different chemical geometries to fabricate biomaterials with controllable functionality and other physical/chemical properties (e.g. mechanical properties of cross-linking agents), helping customers to improve the biocompatibility, activity and functionality of polymers that allow for controlled delivery profiles of drug delivery vehicles.
Beyond the diverse product range, CD Bioparticles also provides exceptional customer support, offering expert guidance and technical assistance to researchers navigating the intricacies of PDMS utilization.
With its expanded PDMS portfolio and unwavering commitment to scientific advancement, CD Bioparticles strives to provide its customers with the most accurate and reliable tools for drug delivery. For more information on the new PDMS, please visit https://www.cd-bioparticles.net/polydimethylsiloxane.
About CD Bioparticles
CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.
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With years of experience in the pharmaceutical and life science sectors, CD Bioparticles has announced a wide range of new Functional Polystyrene Particles with various surface functional groups such as amino, carboxyl and hydroxyl groups for covalent coupling of proteins or other ligands. The new polystyrene particles can be applied in immunoassays, analytical chemistry, and bio-nano interactions research.
Polystyrene microspheres not only exhibit the general properties of polymer microspheres, such as good sphericity, large specific surface area, good surface activity, and uniform and controllable particle size, but also possess some unique characteristics, such as high rigidity, insolubility in common solvents, and non-easy biodegradability. In addition, the benzene ring of polystyrene microspheres has strong reactivity, which can carry out a series of functionalization reactions, so that the surface of the microspheres has a variety of active functional groups, and the properties of polystyrene are better exploited.
Polystyrene particles provide a flexible platform for diagnostic and bioseparation applications. There are several methods for attaching biological ligands to polystyrene particles, including adsorption onto plain polystyrene particles, covalent adsorption onto surface functionalized particles, and attachment of ligands of interest onto particles precoated with binding proteins (e.g., streptavidin, protein A, or protein G).
CD Bioparticles now offers multiple functional polystyrene particles with various surface functional groups, such as amino, carboxyl and hydroxyl groups for covalent coupling of proteins or other ligands. They can be designed with Acrylate surface and supplied in water, with Alkyl-OH surface coatings to significantly reduce the non-specific binding of proteins, with Amine groups on the surface and Amine PS/DVB Particles, and also functionalized with COOH groups on the surface and Carboxyl Porous PS/DVB Particles cross-linked with 0.5% DVB.
These new functionalized polystyrene particles can be used for a variety of applications, including organic synthesis, analytical chemistry, drug delivery materials, bioimaging, labeling, and immunoassays. They demonstrate excellent stability, high binding capacity and ultra-high specificity (low background) and have been extensively validated in academic and industrial scale immunoturbidimetric assays.
For example, the DiagPoly™ Amine Polystyrene Particles, 0.025 μm (Cat. No. DFO-L026) are functionalized with amine groups (NH2) on the surface for covalent attachment of proteins, peptides and nucleic acids. These particles can be utilized as standards or markers, in immunoassays (such as latex agglutination assays and solid phase enzyme immunoassays), or coated with proteins for use in research and diagnostic tests.
In addition to the carboxyl and amino functionalized particles, CD Bioparticles also offers larger functionalized particles and different surface chemicals such as epoxy, PEG, NHS, and cycloalkane click chemicals.
CD Bioparticles' Functional Polystyrene Particles are available in a variety of sizes and functional groups. For more information, please visit https://www.cd-bioparticles.com/products/functional-polystyrene-particles-320.html.
About CD Bioparticles
CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.
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CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, has announced the launch of its new line of Polyamino Acids for the research community, including the mPEG-PCL-PLG, mPEG-PLGA-PGA, and PCL-b-PASP. These new polymers are designed to provide a more versatile and effective way for scientists working in the field of drug delivery.
Poly(amino acids) are naturally occurring biocompatible and biodegradable synthetic linear polymers composed of amino acids as monomeric units. These polymers mainly contain the poly(acidic amino acids) (e.g., poly(l-glutamic acid) (PLG) and poly(aspartic acid)), and the poly(basic amino acid) (e.g., polylysine (PLL) and polyarginine).
Poly (amino acids) have several potential advantages as biomaterials. A large number of polymers and copolymers can be prepared from various amino acids. Side chains provide sites to attach small peptides, drugs, cross-linking agents, or dangling groups that can be used to modify the physical and mechanical properties of the polymers. Since these polymers release natural amino acids as the major products of polymer backbone cleavage, their degradation products have low systemic toxicity.
Extensive research has thus been conducted on the use of poly (amino acids) as functional materials, leading to the development of bioactive peptides that can be used in biological fields such as tissue engineering, regenerative medicine and drug/gene delivery systems. Poly(amino acids) also have significant biological functions such as targeting specificity and easy metabolism of their degradation products. Based on these properties, various poly (amino acid) materials hybridized with synthetic polymers have also been investigated as functional materials.
CD Bioparticles now offers researchers worldwide a variety of Polyamino Acids with unique properties and sizes for drug delivery applications, including the mPEG-PCL-PLG, mPEG-PLGA-PGA, mPEG-PLGA-PLL, and PCL-b-PASP. CD Bioparticles’ mission is to help customers reduce the burden of cumbersome chemical synthesis, formulation and purification processes, better track and image the distribution of polymeric (nano) materials, reduce immune or xenobiotic reactions generated by the materials, and increase the drug-loading efficiency and yield of drug delivery materials.
In addition, CD Bioparticles has a wide range of functional groups/targeting ligands/labels for loading, modification, specific targeting, tracking and detection of polymers and the company can improve the biocompatibility, activity and functional properties of polymers to enable controlled delivery profiles for drug delivery vehicles. Furthermore, CD Bioparticles can help produce biomaterials with controlled functionality and other physical/chemical properties (e.g., mechanical properties of cross-linkers) from non-GMP small laboratory scale to GMP and non-GMP commercial scale.
CD Bioparticles is committed to providing its customers with the most accurate and reliable tools for drug delivery. For more information on the new Polyamino Acids, please visit https://www.cd-bioparticles.net/polyamino-acids-plga.
About CD Bioparticles
CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.
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