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on July 26, 2024
Full Name:
Angiotensin I Converting Enzyme 2 (ACE2)
Function:
ACE2 is an essential counter-regulatory carboxypeptidase within the renin-angiotensin hormone system, playing a crucial role in regulating blood volume, systemic vascular resistance, and cardiovascular homeostasis. It catalyzes the conversion of angiotensin I into angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects on cardiomyocytes, and angiotensin II into angiotensin 1-7, which acts as a vasodilator and anti-proliferative agent, counteracting the effects of the vasoconstrictor angiotensin II. Additionally, ACE2 removes the C-terminal residue from other vasoactive peptides, including neurotensin, kinetensin, and des-Arg bradykinin, but is inactive on bradykinin. It also efficiently cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin), and dynorphin A.
The C-terminus of ACE2 shares homology with collectrin and is involved in trafficking the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells, regulating its surface expression and catalytic activity.
Check our ACE2 antibody flow cytometry
Posted in: Technology
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