Topic: biotech

Nanogels (NGs), namely nanoscale hydrogel particles, are three-dimensional network systems formed by physical or chemical cross-linking of polymers. Nanogels have received widespread attention in recent years due to their unique properties and potential applications in various fields such as drug delivery, tissue engineering, and diagnostics. Classification of Nanogels According to the phase change triggering mechanism of nanogels, nanogels can be divided into ordinary nanogels and environ...

Coupling drugs combine the precise targeting and potent killing properties, has become a widely recognized form of medication in recent years. Radioactive drug conjugates (RDCs), as a particular form of coupling drugs, are formed by combining radioactive isotopes with disease-targeting molecules. According to the application of RDCs, they can be divided into two main categories: diagnostic RDCs and therapeutic RDCs. γ-emitting isotopes are selected for diagnosis because the radiation they pro...

The classical mode of action of small molecule drugs is "occupancy-driven". Since the FDA approved the first oral small molecule targeted therapy for tumors-tamoxifen targeting the estrogen receptor (ER)-in 1977 for the treatment of breast cancer, small molecule drug development has typically focused on screening for high-affinity inhibitors. Small molecule inhibitors can bind to the active sites or allosteric sites of proteins to abolish their function, which is an “occupancy (of a specific sit...

BOC Sciences, a globally renowned supplier with over a decade of experience in the biochemical supply chain, is thrilled to announce its participation in this year's TIDES USA or the Oligonucleotide and Peptide Therapeutics conference. The BOC Sciences team will showcase its cutting-edge products and services at booth #937. TIDES USA 2024 is to be held in Boston from May 14 to 17, 2024, gathering industry leaders across the biotechnology and pharmaceutical landscape. It's regarded as the larg...

There are various techniques for the preparation of microspheres, and the selection of an appropriate method depends on the physicochemical properties of the drug. Currently, the most widely used methods include emulsion evaporation, phase separation, spray drying, and hot-melt extrusion, each with corresponding products on the market. Emulsion Evaporation Method The solvent evaporation method is the most widely applied technique for microsphere preparation. In industrial production, it ca...

BOC Sciences, a tech-driven company, is delighted to announce that its team will be participating in the prestigious Drug Discovery Chemistry (DDC) conference in April 2024. The company will be situated at booth #117, showcasing its quality chemical materials and advanced technologies. DDC is an annual event that gathers researchers, scientists, and experts from across the globe who are involved in the dynamic field of drug discovery. DDC builds a perfect bridge for thought-sharing and networ...

In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. What are their similarities and differences? What are their respective advantages? What is the current status of research and development? What are the prospects? This article analyzes each aspect. Definitions ...

Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. Nielsen (University of Copenhagen), Michael Egholm (University of Copenhagen), Rolf H. Berg (Risø National Laboratory), Technical University of Denmark) and Ole Buchardt (University of Copenhagen) invented it in 1991. Applications of PNA include altering gene expression, serving as inhibitors and promoters, antigene and antisense ...

In recent years, various nucleic acid-based therapies (NBT) have emerged as effective and specific activators of endogenous gene expression. Unlike gene therapy approaches supplementing gene expression, RNA-targeted therapy enhances protein production by selectively modulating cellular mechanisms mediated by endogenous RNA, such as transcription, splicing, translation, mRNA stability, and subcellular localization. Currently, the US Food and Drug Administration (FDA) and the European Medicines...

The COVID-19 pandemic has killed millions of people. Vaccines certainly are the most outstanding ways to prevent major diseases and death, though they haven't eliminated infections. At present, the most effective vaccine is the mRNA vaccine developed by Pfizer-BioNTech and Moderna. Before that, mRNA technology stopped in the lab phase. How to apply mRNA technology to more complex diseases in the future? The ideal and safe delivery vector may be the answer. Although lipid nanoparticles (LNPs) ...

Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, as well as lung cancer. Its novel and complex chemical structure, extensive and significant biological activity, unique mechanism of action, and scarce natural resources have gained immense favor among botanists, chemists, pharmacologists, and molecular biologists, making it a prominent anticancer sta...

The cosmetics and skincare industry is constantly evolving and a recent trend that has emerged is the use of fermented ingredients in skincare products. Fermentation is a microbial metabolic process that has been used for centuries in food and beverage production, and now it has been extended to the cosmetic industry. What are Fermented Raw Materials? Fermented raw materials are natural ingredients that have undergone a fermentation process. The substrates of fermentation utilized in cosme...