by on May 24, 2024
The breakthroughs achieved within the scientific world continue to baffle the layman. We owe a significant chunk of these advancements to the realm of biochemistry, specifically amino acid products, peptide products, and peptide nucleic acid (PNA) monomers. Together, these components contribute significantly to understanding the stupefying wonders of life down to our very cells.   If we consider the biological perspective, amino acids serve as the building blocks for proteins. They are cen...
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by on May 24, 2024
Antibody-drug conjugates (ADCs) represent a rapidly developing field within pharmaceutical biotechnology. ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic or radioactive compound. They combine the specificity of antibodies, which enables specific target cell binding, and the cell-killing activity of cytotoxic drugs, providing a method of delivering these agents directly to cancer cells.   Antibody modification and conjugation ...
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by on May 24, 2024
Proteolysis Targeting Chimeras (PROTACs) are emerging as a promising therapeutic tool in the world of molecular and medical biology. As the daunting complexity of diseases unfolds, the need for more precise and targeted tactics to mitigate pathological conditions is intensifying. PROTACs have novel pharmaceutical potential, enabling the degradation of disease-causing proteins, and offering a fresh perspective to traditional activity-inhibition strategies.   Understanding PROTACs ...
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by on May 24, 2024
Lipids, a broad group of naturally occurring molecules, continue to play a significant role in various chemical processes. The analysis and characterization of lipids are critical steps in achieving effective chemical practices in several industries, including the chemical industry. Lipids can function as bio-active compounds in pharmaceuticals, ingredients in cosmetic products, and additives in biofuel production. Their diverse group of fats, oils, sterols, waxes, and other related compounds, p...
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by on April 25, 2024
Nanogels (NGs), namely nanoscale hydrogel particles, are three-dimensional network systems formed by physical or chemical cross-linking of polymers. Nanogels have received widespread attention in recent years due to their unique properties and potential applications in various fields such as drug delivery, tissue engineering, and diagnostics. Classification of Nanogels According to the phase change triggering mechanism of nanogels, nanogels can be divided into ordinary nanogels and environ...
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by on April 25, 2024
Coupling drugs combine the precise targeting and potent killing properties, has become a widely recognized form of medication in recent years. Radioactive drug conjugates (RDCs), as a particular form of coupling drugs, are formed by combining radioactive isotopes with disease-targeting molecules. According to the application of RDCs, they can be divided into two main categories: diagnostic RDCs and therapeutic RDCs. γ-emitting isotopes are selected for diagnosis because the radiation they pro...
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by on April 25, 2024
The classical mode of action of small molecule drugs is "occupancy-driven". Since the FDA approved the first oral small molecule targeted therapy for tumors-tamoxifen targeting the estrogen receptor (ER)-in 1977 for the treatment of breast cancer, small molecule drug development has typically focused on screening for high-affinity inhibitors. Small molecule inhibitors can bind to the active sites or allosteric sites of proteins to abolish their function, which is an “occupancy (of a specific sit...
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by on April 25, 2024
BOC Sciences, a globally renowned supplier with over a decade of experience in the biochemical supply chain, is thrilled to announce its participation in this year's TIDES USA or the Oligonucleotide and Peptide Therapeutics conference. The BOC Sciences team will showcase its cutting-edge products and services at booth #937. TIDES USA 2024 is to be held in Boston from May 14 to 17, 2024, gathering industry leaders across the biotechnology and pharmaceutical landscape. It's regarded as the larg...
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by on March 26, 2024
There are various techniques for the preparation of microspheres, and the selection of an appropriate method depends on the physicochemical properties of the drug. Currently, the most widely used methods include emulsion evaporation, phase separation, spray drying, and hot-melt extrusion, each with corresponding products on the market. Emulsion Evaporation Method The solvent evaporation method is the most widely applied technique for microsphere preparation. In industrial production, it ca...
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by on March 26, 2024
BOC Sciences, a tech-driven company, is delighted to announce that its team will be participating in the prestigious Drug Discovery Chemistry (DDC) conference in April 2024. The company will be situated at booth #117, showcasing its quality chemical materials and advanced technologies. DDC is an annual event that gathers researchers, scientists, and experts from across the globe who are involved in the dynamic field of drug discovery. DDC builds a perfect bridge for thought-sharing and networ...
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by on March 26, 2024
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. What are their similarities and differences? What are their respective advantages? What is the current status of research and development? What are the prospects? This article analyzes each aspect. Definitions ...
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by on March 26, 2024
Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. Nielsen (University of Copenhagen), Michael Egholm (University of Copenhagen), Rolf H. Berg (Risø National Laboratory), Technical University of Denmark) and Ole Buchardt (University of Copenhagen) invented it in 1991. Applications of PNA include altering gene expression, serving as inhibitors and promoters, antigene and antisense ...
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