CD BioSciences, a US-based biotechnology company focusing on the development of imaging technologies, is proud to announce the launch of its new Multicolor Immunofluorescence Staining Kits. These kits empower researchers to achieve high-quality staining of tissues and cells utilizing 2-7 different colors, enabling more detailed and comprehensive analysis.
By providing researchers with the tools they need to achieve exceptional multicolor staining, CD BioSciences is committed to supporting groundbreaking discoveries across various fields of biological research. These new Multicolor Immunofluorescence Staining Kits are specifically designed for high-quality staining of human and small mammalian tissue sections and cells. With CD BioSciences’ advanced staining solutions, scientists can enhance their research by obtaining accurate and reliable results and unlock deeper insights into their samples.
Utilizing advanced technologies like Tyrosine Signal Amplification (TSA), these kits provide superior signal amplification and exceptional staining quality, particularly for human and small mammal samples. TSA utilizes HRP-conjugated secondary antibodies to catalyze the stable covalent binding of fluorescein substrate to antigen and amplify the fluorescent signal. In addition, the double immunofluorescence (IF) procedure is designed to detect the co-distribution of two different antigens in the same sample.
With these advancements, CD BioSciences’ Multicolor Immunofluorescence Staining Kits offer researchers a versatile and powerful solution for a wide range of applications. For example, the 7-Color mIF Staining Kit for Mouse Tissue, TSA (Catalog No. MCIS001) can be used for immunofluorescence staining of tissues, paraffin sections and TMA. This 7-color mIF Staining Kit utilizes TSA technology to efficiently detect 7 different antigens on mouse tissue or cell samples when paired with user-supplied rabbit primary antibodies. Multiple labeling can be achieved by using a heat repair method to remove non-covalently bound antibodies and performing a second round of incubation with the next primary antibody and another fluorogenic substrate.
2-Color IF Staining Kit for Mouse (Green) and Rabbit (Red) antibody (Catalog No. MCIS013) can be applied in IHC, ICC/IF, Flow, paraffin and frozen sections. The tissue microenvironment contains complex cellular components, and researchers can detect and identify different compositions through multiple immunofluorescence staining. This new 2-Color IF Staining Kit is paired with user-supplied mouse and rabbit primary antibodies to efficiently detect 2 different antigens on paraffin and frozen sections. The kit’s IF procedure is designed to detect the co-distribution of two different antigens in the same sample. Dual immunofluorescence staining allows simultaneous detection of mouse and rabbit primary antibodies. Please note that all of these kits are for research use only.
CD BioSciences offers Multicolor Immunofluorescence Staining Kits to empower researchers to explore the intricate details of cellular and tissue structures with unprecedented accuracy and sensitivity. To learn more about the new kits, please visit https://www.bioimagingtech.com/multicolor-immunofluorescence-staining-kits.html.
About CD BioSciences
CD BioSciences is a biotechnology company committed to the development of imaging technology for many years. Its scientists can utilize high-content imaging, nanoparticle imaging, imaging flow cytometry, time-lapse imaging, and other techniques to image cell structure, cell migration, cell proliferation, pathogen infection mechanisms, and interactions between protein molecules.
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CD BioSciences, a US-based biotechnology company focusing on the development of imaging technologies, proudly announces an extensive portfolio of Nervous System Tissue Microarrays designed to support neuroscience research. This comprehensive collection provides researchers with a unique resource to study various neurological conditions and accelerate their investigations into neurological diseases and disorders.
CD Bioscience has been developing imaging technologies for many years and uses high content imaging, nanoparticle imaging, imaging flow cytometry, time-lapse imaging and other technologies to image cellular structures, cell migration, cell proliferation, pathogen infection mechanisms and protein molecule interactions. In addition, the company has a team of professionals with extensive experience in the imaging field and can provide customers with personalized imaging services to meet their research needs in the fields of biology, microbiology, medicine and food.
CD BioSciences now offers a comprehensive portfolio of Nervous System Tissue Microarrays, including Brain Tissue Microarrays and Head & Neck Tissue Microarrays. This comprehensive offering provides researchers with a powerful tool for studying various neurological disorders, including brain tumors, head and neck cancers, and neurodegenerative diseases.
For example, Multiple Sites of Normal Brain Tissue Microarray, 80 Cases, 26 Cores (Catalog NO. NBCT003) is a tissue microarray consisting of normal brain tissue from multiple sites, including different regions of the brain. It contains 3 cases each of frontal lobe, apical lobe, occipital lobe, temporal lobe, midbrain, pons, medulla oblongata, thalamus opticus, cerebellum, hippocampus, callositas, optic nerves, and spinal cord tissue, and 1 case of caudate nucleus. Each case has duplicate cores for each block.
Head and Neck Cancer Tissue Microarray, 80 Cases, 80 Cores (Catalog NO. NBCT044) can be used for IHC, ISH and other routine histology procedures. This tissue microarray is created using head and neck cancer samples and tongue tissue, and it includes 57 cases of squamous cell carcinoma, 3 cases of undifferentiated carcinoma, 1 case of sarcomatoid carcinoma, 8 cases of metastatic squamous cell carcinoma, 7 cases of tongue tissue, 2 cases of salivary gland tissue, and 1 case each of sublingual gland tissue and parotid gland tissue. Each case has one nuclear core.
These microarrays allow researchers to conduct efficient and cost-effective studies on various neurological conditions, accelerating discoveries with the potential to improve patient outcomes. In addition, CD BioSciences is continually expanding its portfolio to provide scientists with more efficient tools to analyze multiple nervous system tissue samples simultaneously, facilitating in-depth investigations into disease mechanisms, biomarker discovery, and drug development.
With a focus on innovation and precision, CD BioSciences has developed state-of-the-art Nervous System Tissue Microarrays to allow scientists better study nervous tissue samples and advance neuroscience research. To learn more about the new products, please visit https://www.bioimagingtech.com/nervous-system-tissue-microarrays.html.
About CD BioSciences
CD BioSciences is a biotechnology company committed to the development of imaging technology for many years. Its scientists can utilize high-content imaging, nanoparticle imaging, imaging flow cytometry, time-lapse imaging, and other techniques to image cell structure, cell migration, cell proliferation, pathogen infection mechanisms, and interactions between protein molecules.
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CD BioSciences, a US-based biotechnology company focusing on the development of imaging technologies, is delighted to announce the addition of a new line of IHC Ancillaries to its product portfolio, including deparaffinators, retrievers and enzymes, washers and detergents, diluents and blockers, and mounting media. These ancillaries are developed to facilitate IHC research and diagnostics, enabling scientists, pathologists, and clinicians to achieve more accurate and reliable results.
Immunohistochemical staining depends on many different factors that can affect the staining results. Committed to advancing scientific discovery, CD BioSciences offers a wide range of reagents to ensure high quality staining and reliable, accurate results under optimal conditions each time antibodies are applied to tissue. These new IHC tools are available in component form and are easy to use. They are also supplied in a variety of sizes to meet the needs of different laboratories.
For example, the Retriever 20X with Citrate (Catalog NO: IHA040101) is designed for heat-induced epitope or nucleic acid retrieval procedures for immunohistochemistry (IHC), immunocytochemistry (ICC), immunofluorescence (IF), and in situ hybridization (ISH) of nucleic acids (CISH or FISH). It can be used to perform immuno or nucleic acid staining on formalin-fixed, paraffin-embedded tissue sections. This product can be utilized for any antigen or nucleic acid and promotes standardization of pretreatment procedures, resulting in more consistent and reliable results. It should be noted that this product is not intended for use in humans or animals.
Permanent Mounting Media (Catalog NO: IHA040109) is a non-toxic, biodegradable permanent mounting medium designed for the preservation of immunohistochemical and CISH stainings. It is ideal for mounting cell or tissue sections immunostained with horseradish peroxidase, alkaline phosphatase or other suitable enzymes and their substrate chromogens (e.g., DAB, HRP Black, and AP Blue). This medium is suitable for permanent mounting of cell or tissue samples treated with substrate-chromogen protectors to preserve solvent-sensitive substrate-chromogen stains such as AEC, Fast Red, HRP Blue, HRP Green, Alk Magenta, Alk Scarlet, Alk Red, and Alk Brown.
CD BioSciences offers Background Blocker (Catalog NO: IHA040302) to block or reduce antibody or antigen/nucleic acid-associated backgrounds that produce high backgrounds during IHC, CISH/FISH staining procedures. The reagent minimizes non-specific interactions that may be induced by antibodies or nucleic acids and promotes specific antigen-antibody binding. It can also be used as a diluent for different types of monoclonal, polyclonal, and control antibodies that produce a high background during IHC or CISH/FISH staining procedures.
CD BioSciences offers a series of ancillaries to help researchers and diagnosticians improve the efficiency and accuracy of their IHC assays, empowering scientists to unlock deeper insights into cellular processes and disease mechanisms. To learn more about the new products, please visit https://www.bioimagingtech.com/ihc-ancillaries.html.
About CD BioSciences
CD BioSciences is a biotechnology company committed to the development of imaging technology for many years. Its scientists can utilize high-content imaging, nanoparticle imaging, imaging flow cytometry, time-lapse imaging, and other techniques to image cell structure, cell migration, cell proliferation, pathogen infection mechanisms, and interactions between protein molecules.
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CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, has announced the launch of its new range of In Vivo Imaging Reagents, including fluorescent imaging probes, fluorescent labeling dyes, fluorescent imaging panels, and fluorescent nanoparticles, designed to provide researchers with a non-invasive approach to visualize and quantify cellular and biological functions in living systems.
In vivo fluorescence imaging is a non-invasive method for visualizing and quantifying cellular and biological functions. Using these biospecific, validated fluorescent probes, dyes and panels, scientists can visualize disease pathogenesis and related biological processes in living systems. In certain preclinical studies, fluorescence can reveal disease processes and therapeutic effects earlier and more powerfully, making it an attractive alternative to standard imaging methods. There are many advantages to using in vivo fluorescence imaging for scientific research.
CD BioSciences now provides customers with fluorescent imaging probes, fluorescent label dyes, fluorescent imaging plates and fluorescent nanoparticles for scientific research. In addition, the company offers bioluminescent substrates and lentiviral particles, bioluminescent tumor cell lines, bioluminescent bacterial strains, and microbubble contrast agents. The company's commitment to innovation and quality is evident in the development of these reagents, which are expected to revolutionize the field of in vivo imaging.
For example, the Pan Cathepsin Fluorescent Probe (Catalog NO: VIR030106) can be used for imaging various disease-related events. Proteases play an important role in protein regulation. Lysosomal proteases are a class of proteases whose altered activity predicts many disease-related processes such as cancer, inflammation, arthritis, and cardiovascular disease. The progression and severity of these diseases can be tracked and analyzed by detecting and quantifying normal and altered protease chelator protein activities in vivo. Pan Cathepsin fluorescent probes are versatile pan-trypsin-activatable near-infrared agents for imaging various disease-related events. These activatable probes are optically silent in the intact state and become highly fluorescent upon protease-mediated cleavage and activation.
Fluorescent Cell Labeling Dye (Catalog NO: VIR030201) allows the labeling and tracking of mammalian cells, including stem cells, T cells, and macrophages. This product is a near-infrared fluorescent lipophilic labeling dye that intercalates into the cell membrane. With high solubility and excellent stability, Fluorescent Cell Labeling Dye provides excellent brightness and uniform labeling, making it ideal for in vitro cell detection and longitudinal in vivo cell tracking in a variety of applications, including inflammation, immunology, and stem cell research.
CD BioSciences offers Oncology Fluorescent Imaging Panel (Catalog NO: VIR030306) to help customers maximize in vivo imaging preclinical cancer research. The development of novel, safer cancer therapies that target specific molecular targets and broader disease-related processes is critical in the fight against this disease. This new panel contains six carefully selected fluorescent probes that enable researchers to visualize and quantify various tumor-associated biological processes, providing a better understanding of the disease and aiding in the development of new cancer therapies.
For more information about CD BioSciences' new range of In Vivo Imaging Reagents, please visit https://www.bioimagingtech.com/in-vivo-imaging-reagents.html.
About CD BioSciences
CD BioSciences is a biotechnology company committed to the development of imaging technology for many years. Its scientists can utilize high-content imaging, nanoparticle imaging, imaging flow cytometry, time-lapse imaging, and other techniques to image cell structure, cell migration, cell proliferation, pathogen infection mechanisms, and interactions between protein molecules.
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CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, has announced the launch of its innovative line of Chromogenic Substrates for immunohistochemistry (IHC). These cutting-edge substrates offer superior signal sensitivity, long-term storage stability, enhanced safety, and user-friendliness, empowering researchers to unlock deeper insights into protein expression and function within tissues.
Immunohistochemistry is the study of the localization, characterization, and relative quantification of peptides and proteins in tissue cells using the antigen-antibody reaction, in which an antigen specifically binds to an antibody and a chemical reaction results in the visualization of dyes such as fluorescein and other chromogens, as well as enzymes, metal ions and isotopes, and other chemicals that label the antibody.
IHC has a wide range of applications. For instance, it is widely used to diagnose abnormal cells, such as those found in cancerous tumors, by using specific molecular markers to characterize specific cellular events, such as proliferation or cell death (apoptosis). Additionally, IHC is widely used to understand the distribution and localization of biomarkers and differentially expressed proteins in different parts of biological tissues. Recognizing the wide range of applications for IHC, CD BioSciences has developed a variety of chromogenic substrates, each with high signal sensitivity, to provide customers with a research tool that is stable for long-term storage, sensitive, safe and easy to use.
For example, the HRP Blue Plus Substrate-Chromogen Kit (Catalog NO: SCI020108) is designed for use with peroxidase detection systems and allows the detection of cellular antigens or nucleic acids in paraffin-embedded tissues, cryostat sections, cytosmears, and cell preparations. The substrate chromogen is the final step in the detection process, allowing the antibody-antigen complex to be viewed under a light microscope. This occurs because HRP Yellow acts as an electron donor in the presence of the enzyme horseradish peroxidase. HRP Yellow is oxidized and produces a yellow color at the site of the target antigen or nucleic acid. It is particularly useful for dual staining or multiplex IHC or CISH applications.
For HRP Detection Systems, the ready-to-use ALK Blue Substrate-Chromogen (Catalog NO: SCI020201) is suitable for use in immunohistochemical, immunocytochemical, and in situ hybridization procedures utilizing alkaline phosphatase detection systems. It is for in vitro diagnostic use only and is not intended for use in humans or animals.
CD BioSciences is committed to advancing IHC technology and empowering researchers with the tools they need to make breakthrough discoveries. The dedicated team of scientists at CD BioSciences has developed these next-generation substrates to overcome a variety of challenges and provide researchers with a powerful tool for deciphering the complex language of proteins in tissues.
CD BioSciences chromogenic substrates are specifically designed to elevate tissue analysis to new heights. For further information, please visit https://www.bioimagingtech.com/substrate-chromogens-for-immunohistochemistry.html.
About CD BioSciences
CD BioSciences is a biotechnology company committed to the development of imaging technology for many years. Its scientists can utilize high-content imaging, nanoparticle imaging, imaging flow cytometry, time-lapse imaging, and other techniques to image cell structure, cell migration, cell proliferation, pathogen infection mechanisms, and interactions between protein molecules.
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CD BioSciences, a US-based CRO serving the global life science research community, has announced the launch of its new services to study the Mechanistic Target of Rapamycin (mTOR) in diabetes and metabolism research.
The mechanistic Target of Rapamycin is a serine/threonine protein kinase that is inhibited by rapamycin, a bacterial compound originally isolated from Easter Island soil that inhibits the proliferation of eukaryotic cells. The mTOR protein kinase is present in two distinct complexes, mTOR complex 1 (mTORC1) and mTORC2, each of which contains different protein components and phosphorylates different substrates.
mTOR is a key regulator of metabolic homeostasis. These functions are primarily performed by mTORC1, which ensures that the cell’s anabolic and catabolic processes are linked to environmental cues, including nutrient levels and growth factors. Under pro-growth conditions, mTORC1 is activated and promotes cellular biogenesis while actively inhibiting energy-generating processes such as autophagy. Autophagy is a key cytolytic process, and mTORC1 kinase is the most potent inhibitor of autophagy initiation in mammals. mTORC1 also plays a key role in the terminal phase of autophagy, where nutrients recycled by autophagy stimulate mTORC1-driven lysosomal biogenesis. mTORC1 is required for this late activity to prolong autophagy.
In addition, the role of mTOR in the development and regulation of the immune system is rapidly emerging. Insights into this paradigm are expected to link the regulation of pathways to the restoration of immune homeostasis for the treatment of a wide range of diseases, including infectious diseases, autoimmune disorders, allograft rejection and malignancies.
To help scientists better understand the regulation and role of mTOR in metabolic regulation and to address some of the major unanswered questions, CD BioSciences has developed a series of research solutions, empowering researchers to delve into the intricate world of metabolic signaling pathways. In addition, the company’s research team possesses the experience and expertise to provide customized metabolic research and development solutions.
CD BioSciences can help scientists identify key regulators, decipher their molecular functions, elucidate their regulatory mechanisms, and translate these insights into cellular and animal models, paving the way for targeted drug discovery and therapy development. Through meticulous scientific rigor and cutting-edge technologies, CD BioSciences bridges the gap between fundamental research and impactful solutions for metabolic diseases.
CD BioSciences provides cost-effective and quality metabolic research solutions to clients worldwide to successfully translate new knowledge into effective therapies for metabolic diseases. For more information on metabolic research solutions or other pathways, please visit CD BioSciences at https://www.cd-biosciences.com/diabetes-metabolism.html.
About CD BioSciences
CD BioSciences is a trusted research product supplier and CRO based in New York. With high-quality reagents and comprehensive services, CD BioSciences is a one-stop shop devoted to advancing signaling pathway studies for researchers. The company is committed to fulfilling all demands in the research of signaling pathways and provides high-quality reagents and comprehensive solutions to support innovative discoveries.
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CD BioSciences, a US-based CRO serving the global life science research community, has announced the launch of its comprehensive research solutions for the scientific community to gain insights into glucose homeostasis. The company’s research team has developed several metabolic research solutions that could help advance the development of new treatments for diabetes and other metabolic disorders.
Diabetes, which affects approximately 170 million people worldwide, is a disease characterized by a failure of glucose homeostatic control. This disorder results from a combination of insulin resistance and inadequate insulin secretion, leading to chronic hyperglycemia. Because diabetes is characterized by hyperglycemia, elucidating defects in the hypothalamic hormone and nutrient sensing pathways that regulate glucose homeostasis will reveal the core factors that contribute to the perpetuation of this metabolic disease.
Glucose homeostasis reflects the balance between dietary carbohydrate intake and the uptake and utilization of glucose by peripheral tissues. Insulin, secreted by the pancreas, is the primary regulator of glycemia. In the fasting state, low insulin levels promote glucose production via hepatic gluconeogenesis and glycogenolysis and inhibit glucose uptake by insulin-sensitive tissues (skeletal muscle and adipose) to maintain euglycemia. When blood glucose or insulin levels are low or during exercise, glucagon is secreted by pancreatic alpha cells, which stimulate glycogenolysis and gluconeogenesis in the liver and, to a lesser extent, the kidneys. Postprandial glucose uptake causes an increase in insulin and a decrease in glucagon, resulting in the opposite process. Insulin stimulates glucose uptake by peripheral tissues. Most postprandial glucose is used by skeletal muscle. Some tissues, most notably the brain, utilize glucose in the absence of insulin. Other factors such as neural stimulation, metabolic signaling, and other hormones also play a role in glucose metabolism.
Glucose homeostasis is critical to human health and maintaining adequate blood glucose levels is essential for survival. On the other hand, inappropriate glucose levels in the blood are a major symptom of diabetes. Normal glucose homeostasis is mainly maintained by glucagon and insulin. Therefore, it is necessary to elucidate and understand the underlying mechanisms of the various interactions in order to improve existing antidiabetic therapies and drugs and to develop new therapeutic approaches.
CD BioSciences now offers comprehensive solutions for studying metabolic signaling pathways, particularly glucose homeostasis, including Regulator Characterization, Regulator Identification, Mechanism Study, Phenotype Analysis, Animal Model Generation, Chemical Screening, and Therapy Development. The company’s research team possesses the experience and expertise to provide customized metabolic research and development solutions.
CD BioSciences provides cost-effective, high-quality, and hassle-free metabolic research solutions to customers worldwide. For more information on metabolic research solutions or other pathways, please visit CD BioSciences at https://www.cd-biosciences.com/diabetes-metabolism.html.
About CD BioSciences
CD BioSciences is a trusted research product supplier and CRO based in New York. With high-quality reagents and comprehensive services, CD BioSciences is a one-stop shop devoted to advancing signaling pathway studies for researchers. The company is committed to fulfilling all demands in the research of signaling pathways and provides high-quality reagents and comprehensive solutions to support innovative discoveries.
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CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, has announced the expansion of its portfolio to include a comprehensive line of Embedding Resins and Kits for electron and light microscopy. These kits offer a convenient and standardized approach for researchers to embed specimens for histological applications.
Embedding resins and kits play a vital role in electron microscopy technology by providing a stable support matrix for biological specimens to withstand the ultra-thin sectioning process required for high-resolution imaging. CD Bioscience now offers a wide range of Embedding Resins and Kits for use in electron and light microscopy, each with unique properties suited for specific applications.
For example, the Non-Polar Embedding Resin Kits (Catalog NO: EMB010309) are highly purified, three-component systems that are precisely formulated to utilize long wavelength (360 nm) UV light and photopolymerization kinetics at temperatures as low as -80°C. These resins are also referred to as low temperature UV methacrylate resins. All kits are suitable for freezing substitution of samples. The low viscosity allows better retention of cellular ultrastructure, improved preservation of antigenicity, and greatly reduced background labeling. The products can also be used at room temperature and produce high contrast TEM images of unstained thin sections.
CD Bioscience also offers tissue embedding medium to meet the specific needs of research applications, such as the Tissue Embedding Medium, with DMSO (Catalog NO: EMB010102). A small amount of dimethyl sulfoxide (DMSO) has been added to this product to accelerate tissue penetration. This slight change in composition typically reduces penetration time by one third. It has good sectioning characteristics and produces excellent wrinkle-free sections down to a thickness of 4 microns while maintaining excellent band continuity. For hard tissue specimens, this formulation produces a more pliable band from hard, brittle sections. The product is double filtered so no further filtration is required prior to use. And the removal process is always free of staining residue.
In addition, CD Bioscience provides a wide range of embedding media like the Aqueous Mounting Medium (Catalog NO: EMB010204). This Mounting Medium is designed and optimized for immunostaining and immunohistochemistry applications. It dries extremely quickly, allowing coverslips to be applied to slides and then immediately examined by light microscopy. The dropper bottle packaging eliminates the hassle of transferring mounting media from a large container to a small bottle for individual specimens and, of course, the waste of unused media. It allows controlled dispensing without the use of additional droppers or glass rods, and its low viscosity allows the media to flow easily, inhibiting bubble formation and adsorption.
CD BioSciences embedding kits are ideal to meet the diverse needs of researchers in various fields. For further information, please visit https://www.bioimagingtech.com/embedding-resins-and-kits.html.
About CD BioSciences
CD BioSciences is a biotechnology company committed to the development of imaging technology for many years. Its scientists can utilize high-content imaging, nanoparticle imaging, imaging flow cytometry, time-lapse imaging, and other techniques to image cell structure, cell migration, cell proliferation, pathogen infection mechanisms, and interactions between protein molecules.
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CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, has announced the launch of its 3D Image Analysis Services for researchers, from data processing and analysis to custom report generation.
Pathogenesis, prevention and treatment of many diseases require pathological studies. Microscopic image analysis of tissues is the basis for a wide range of pathology studies, which require the collection of a small number of tissue samples from a patient. After staining the samples, researchers use visible light or fluorescence for visual analysis. Due to the inherent three-dimensional nature of biological tissues, life science research and exploration requires in-depth studies based on three-dimensional spatial information of biological tissues.
Traditional two-dimensional tissue analysis methods limit the analysis of small subregions of tissues, fail to analyze complex tissues, and cannot provide three-dimensional (3D) information about tissues. In recent years, 3D tissue imaging has become a tool for 3D tissue analysis, greatly facilitating basic biological research. However, many researchers still face difficulties in analyzing and processing 3D images. Therefore, it is very important to master and apply 3D image analysis software.
Backed by experienced technicians and state-of-the-art software, CD Bioscience offers 3D image analysis services for researchers who are able to implement 3D tissue imaging in the laboratory, but have difficulty in analyzing and processing the large amount of data generated. The team can also prepare detailed analysis reports for clients. In addition, CD Biosciences can provide customers with one-stop 3D tissue imaging services.
Researchers often need to study different biological and drug development issues, such as quantifying tumor volume, fibrosis area, and quantifying the degree of penetration of therapeutic antibodies. For the 3D images generated from different studies, CD Biosciences can design custom 3D image analysis plans and apply computer image analysis software to comprehensively evaluate the tissue samples. Therefore, the delivery time of CD Biosciences’ analysis results may vary depending on the complexity of the project.
CD Biosicence has developed optimized antibody labeling methods for uniform labeling on thin/thick tissue sections. In addition, with multiple immunolabeling, researchers can simultaneously evaluate different cell subpopulations and gain a deeper understanding of biology and drug discovery research.
For workflow, the team often designs a customized analysis plan for customers based on their project. Once the protocol is finalized, the client needs to send the 3D image data obtained from the experiment. The technicians will then analyze the 3D images using professional image analysis software and generate a report for the customer.
CD Biosicence’ experienced scientists can reduce the workload of researchers by assisting in the design and execution of experiments and transforming complex image datasets into easy-to-read reports. For more information, please visit https://www.bioimagingtech.com/3d-image-analysis.html.
About CD BioSciences
CD BioSciences is a biotechnology company committed to the development of imaging technology for many years. Its scientists can utilize high-content imaging, nanoparticle imaging, imaging flow cytometry, time-lapse imaging, and other techniques to image cell structure, cell migration, cell proliferation, pathogen infection mechanisms, and interactions between protein molecules.
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CD BioSciences, a US-based CRO serving the global life science research community, has announced the launch of its new services to study Anabolism in diabetes. The new solutions can help researchers to better understand the the synthesis of molecules.
Metabolism is a series of chemical reactions that occur in living systems. The purpose of metabolism is to convert nutrients into energy and building blocks and to eliminate nitrogenous waste. It can be divided into two categories: catabolism (the breakdown of molecules) and anabolism (the synthesis of molecules). More specifically, anabolism is the process of biosynthesis of cellular material from simple inorganic or organic compounds, while catabolism provides all the energy and, in many cases, the building blocks or precursors for these important biosynthetic reactions.
Metabolism is closely related to the availability of nutrients such as proteins, lipids, and carbohydrates. Metabolic processes are tightly controlled by cell signaling pathways to maintain metabolic homeostasis of the system. Additionally, altered metabolic patterns are a hallmark of cancer.
Metabolic pathways are a series of chemical reactions of metabolism catalyzed by a series of enzymes. However, metabolic signaling pathways are the cellular signaling transductions that respond to metabolic states and regulate cellular events to maintain cellular and organismal homeostasis.
Anabolic and catabolic pathways can regulate skeletal muscle mass. The major anabolic pathway that regulates skeletal muscle protein synthesis is the mTOR/TORC1 signaling. The mechanistic target of rapamycin (mTOR), formerly known as mammalian target of rapamycin, is a master regulator of metabolism and physiology. It integrates signals from insulin, growth factors, oxygen and nutrients. mTOR is found in two multi-protein complexes: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Dysregulation of mTOR activity leads to diabetes, obesity, aging and cancer.
In addition, mTOR regulates cell growth, survival, metabolism and immunity, and overactivation of mTOR promotes tumor growth and metastasis. As a result, many mTOR inhibitors, such as Rapamycin, are approved or in development for the treatment of cancer.
As a trusted CRO, CD BioSciences offers comprehensive solutions covering all aspects of life science research, specifically anabolism, including the Regulator Identification (identification of gene regulators involved in specific metabolic signaling pathways), Animal Model Generation (generation of animal models for specific types of metabolic diseases), Chemical Screening (screening for inhibitors or activators of specific metabolic signaling pathways), and Therapy Development (development of potential therapies for certain types of metabolic diseases).
CD BioSciences provides cost-effective, high-quality and hassle-free metabolic research solutions to scientists worldwide. To learn more about metabolic research solutions or other signaling pathways, please visit CD BioSciences at https://www.cd-biosciences.com/diabetes-metabolism.html.
About CD BioSciences
CD BioSciences is a trusted research product supplier and CRO based in New York. With high-quality reagents and comprehensive services, CD BioSciences is a one-stop shop devoted to advancing signaling pathway studies for researchers. The company is committed to fulfilling all demands in the research of signaling pathways and provides high-quality reagents and comprehensive solutions to support innovative discoveries.
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