CD BioSciences, a US-based CRO serving the global life science research community, has announced the launch of its new services to study Anabolism in diabetes. The new solutions can help researchers to better understand the the synthesis of molecules.
Metabolism is a series of chemical reactions that occur in living systems. The purpose of metabolism is to convert nutrients into energy and building blocks and to eliminate nitrogenous waste. It can be divided into two categories: catabolism (the breakdown of molecules) and anabolism (the synthesis of molecules). More specifically, anabolism is the process of biosynthesis of cellular material from simple inorganic or organic compounds, while catabolism provides all the energy and, in many cases, the building blocks or precursors for these important biosynthetic reactions.
Metabolism is closely related to the availability of nutrients such as proteins, lipids, and carbohydrates. Metabolic processes are tightly controlled by cell signaling pathways to maintain metabolic homeostasis of the system. Additionally, altered metabolic patterns are a hallmark of cancer.
Metabolic pathways are a series of chemical reactions of metabolism catalyzed by a series of enzymes. However, metabolic signaling pathways are the cellular signaling transductions that respond to metabolic states and regulate cellular events to maintain cellular and organismal homeostasis.
Anabolic and catabolic pathways can regulate skeletal muscle mass. The major anabolic pathway that regulates skeletal muscle protein synthesis is the mTOR/TORC1 signaling. The mechanistic target of rapamycin (mTOR), formerly known as mammalian target of rapamycin, is a master regulator of metabolism and physiology. It integrates signals from insulin, growth factors, oxygen and nutrients. mTOR is found in two multi-protein complexes: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Dysregulation of mTOR activity leads to diabetes, obesity, aging and cancer.
In addition, mTOR regulates cell growth, survival, metabolism and immunity, and overactivation of mTOR promotes tumor growth and metastasis. As a result, many mTOR inhibitors, such as Rapamycin, are approved or in development for the treatment of cancer.
As a trusted CRO, CD BioSciences offers comprehensive solutions covering all aspects of life science research, specifically anabolism, including the Regulator Identification (identification of gene regulators involved in specific metabolic signaling pathways), Animal Model Generation (generation of animal models for specific types of metabolic diseases), Chemical Screening (screening for inhibitors or activators of specific metabolic signaling pathways), and Therapy Development (development of potential therapies for certain types of metabolic diseases).
CD BioSciences provides cost-effective, high-quality and hassle-free metabolic research solutions to scientists worldwide. To learn more about metabolic research solutions or other signaling pathways, please visit CD BioSciences at https://www.cd-biosciences.com/diabetes-metabolism.html.
About CD BioSciences
CD BioSciences is a trusted research product supplier and CRO based in New York. With high-quality reagents and comprehensive services, CD BioSciences is a one-stop shop devoted to advancing signaling pathway studies for researchers. The company is committed to fulfilling all demands in the research of signaling pathways and provides high-quality reagents and comprehensive solutions to support innovative discoveries.
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CD BioSciences, a US-based CRO serving the global life science research community, has announced the launch of its new Catabolism research services, which offer researchers a comprehensive range of tools and resources to investigate the role of catabolism in the development and progression of diabetes.
Metabolism describes a series of life-sustaining chemical reactions in an organism that convert nutrients into energy and building blocks and eliminate nitrogenous waste. It can be divided into two categories, catabolism (the breakdown of molecules) and anabolism (the synthesis of molecules). Metabolism is closely related to the availability of nutrients such as proteins, lipids, and carbohydrates. Meanwhile, metabolic processes are tightly controlled by cellular signaling pathways to maintain the metabolic balance of the system. Altered metabolic patterns are one of the hallmarks of cancer.
Metabolic pathways are a series of chemical reactions of metabolism catalyzed by a series of enzymes. However, metabolic signaling pathways refer to cellular signaling transductions that respond to metabolic states and regulate cellular events to maintain cellular and organismal homeostasis. Dysregulation of these pathways has been implicated in metabolic diseases such as obesity and type 2 diabetes, cancer and aging.
Catabolism is an end process of metabolism in which muscle and adipose tissue are broken down into their constituent parts to provide nutrients to the body due to noxious stimuli that cause the organism to be unable to provide itself with sufficient nutrients. However, catabolism is a primary event, which is the brain’s response to perceived or real stress or noxious stimuli, and its secondary role is to inhibit food intake, which breaks down skeletal muscle and adipose tissue to provide nutrients for the organism’s survival.
CD BioSciences strives to be the world’s leading provider of research reagents, services and solutions that help scientists achieve breakthroughs. As a trusted CRO, CD BioSciences offers comprehensive solutions for all aspects of life science research, including catabolism. These solutions for the study of metabolic pathways include, but are not limited to:
1). Regulator Characterization: Studying the molecular function of specific regulators in metabolic pathways.
2). Mechanism study: Investigation of the mechanism of regulation of specific regulators.
3). Phenotype Analysis: Analysis of cellular phenotypes regulated by genes/proteins of interest.
4). Animal Model Generation: Generation of animal models for specific types of metabolic diseases.
5). Chemical Screening: Screening for inhibitors or activators of specific metabolic pathways.
CD BioSciences is committed to providing cost-effective, high-quality and hassle-free metabolic research solutions to customers worldwide. For more about catabolism research solutions or other signaling pathways, please visit CD BioSciences at https://www.cd-biosciences.com/diabetes-metabolism.html.
About CD BioSciences
CD BioSciences is a trusted research product supplier and CRO based in New York. With high-quality reagents and comprehensive services, CD BioSciences is a one-stop shop devoted to advancing signaling pathway studies for researchers. The company is committed to fulfilling all demands in the research of signaling pathways and provides high-quality reagents and comprehensive solutions to support innovative discoveries.
Be the first person to like this.
CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, announced the launch of its new 3D Tissue Imaging Services to researchers with comprehensive solutions for 3D imaging of tissues, including 3D Immunolabeling, Tissue Removal, 3D Imaging, and Quantitative Image Analysis.
Traditional tissue analysis typically uses frozen or paraffin-embedded sections. Micron-thick tissue sections enable the labeling and characterization of individual cells but do not allow the detection of three-dimensional (3D) features of biological samples. Section analysis can only detect and study a portion of a pathological sample, leaving a significant amount of information in the entire pathological tissue untapped. With the development of tissue transparency techniques and the birth of light sheet microscopy, researchers now can perform complete 3D imaging characterization of intact samples.
High-throughput sectioning and optical imaging analysis of tissue samples using traditional tissue analysis techniques are expensive and difficult to obtain 3D information. CD Biosciences can assist researchers using confocal microscopy or light sheet imaging to perform 3D imaging of tissue samples processed with CLARITY technology. Its state-of-the-art laboratory equipment and techniques allow scientists to perform 3D imaging and phenotyping of cell populations throughout the depth of the tissue for biological research.
For 3D tissue imaging, CD Biosciences scientists use CLARITY technology to clean tissues without the need for serial sectioning. This technology preserves spatial relationships and microstructure by forming a more permeable tissue-hydrogel mixture for deep optical inspection, which can be used for 3D mapping and identification of rare markers. In addition, the team analyzes the results using specialized image analysis software to obtain reliable results.
CD Biosciences has developed an optimized antibody labeling method that allows researchers to achieve uniform labeling on thick tissue while maintaining histological integrity. Upon request, CD Biosciences’ research team can use immersion objectives, light sheet microscopes and other imaging methods to perform 3D image analysis on larger tissues. In addition, CD Biosciences offers 3D image analysis services, although some customers only require raw data files from its imaging services.
CD Bioscience has a professional team and advanced imaging equipment to provide customers with a wide range of 3D imaging services. Meanwhile, the entire tissue imaging and analysis process is performed by experienced technicians to ensure the accuracy of the experiment. Customers can also send fixed tissues to CD Bioscience for labeling and imaging, or send labeled tissues to the company for imaging.
CD BioSciences offers a wide range of services including image analysis and consulting. For more information, please visit https://www.bioimagingtech.com/3d-tissue-imaging.html.
About CD BioSciences
CD BioSciences is a biotechnology company committed to the development of imaging technology for many years. Its scientists can utilize high-content imaging, nanoparticle imaging, imaging flow cytometry, time-lapse imaging, and other techniques to image cell structure, cell migration, cell proliferation, pathogen infection mechanisms, and interactions between protein molecules.
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